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It can be clearly found that Organic acids (including Citraconic acid, and p-Coumaric acid ethyl ester, Sebacate), Phenolic acids (Cinnamoyltartaric acid), Terpenoids (Catalpol), Alkaloids (including Caffeoyl-dihydrocaffeoyl spermidine, Bis(Caffeoyl)Spermidine, N1-Caffeoyl-N3-dihydrocaffeoyl spermidine, Bis(Dihydrocaffeoyl)spermidine, N-Caffeoylputrescine, p-Coumaroylputrescine, Putrescine), Amino acids and derivatives (L-Prolyl-L-Phenylalanine, L-Asparagine, Phenylacetyl-L-glutamine, L-Lysine-Butanoic Acid, Homoarginine, L-Arginine, L-Lysine, L-Glutamine) were significantly DR, while Nucleotides and derivatives (including 2'-Deoxyuridine, 2'-Deoxyinosine-5'-monophosphate, Thymidine, 2'-Deoxyguanosine), Flavonoids ( 3,5,6,7,8,3',4'-Heptamethoxyflavone), Terpenoids ( 2,3,23-trihydroxyolean-12-en-28-oic acid, Asperulosidic acid) and lipids ( LysoPE 17:1(2n isomer), LysoPE 14:0(2n isomer), LysoPC 19:2(2n isomer), LysoPC 15:1, LysoPE 16:3, LysoPC 17:0(2n isomer), LysoPC 19:2, LysoPC 17:2) were significantly UR

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"We found that there is a policy implementation gap in smokeless tobacco control, highlighting the need for increased global efforts to reduce the use of the products to catch-up with the progress made in curbing cigarette consumption